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CAS No.: 313-67-7

马兜铃酸A Catalog No. CSN12383

Synonyms: 马兜铃酸 A;Aristolochic acid I;TR 1736

Aristolochic acid A, a natural product isolated and purified from the herb of Aristolochia debilis Sieb. et Zucc. and a potent rephrotoxin, strongly induces toxic damage during ovarian maturation by inhibiting Akt phosphorylation-mediated suppression of apoptosis.

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描述Aristolochic Acid A (Aristolochic acid I), is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum, strongly induces toxic damage during ovarian maturation by inhibiting Akt phosphorylation-mediated suppression of apoptosis. Aristolochic acid A (150, 200 μM, 24 hours) inhibits the cell viabilities of kidney cells HEK293 and HK-2. Aristolochic acid A (100, 200 μM, 24 hours) causes a concentration-dependent decrease in bladder cancer-associated protein (BLCAP) mRNA levels in kidney cells (HEK 293 and HK-2), and bladder cancer cell line (HT-1376). Aristolochic acid A (100, 200 μM, 24 hours) weakens the BLCAP protein signals in a dose-dependent manner in both HEK293 and HT-1376 cells^[3]. AA (Aristolochic Acid A) has been found to damage broilers' kidneys by breaking the redox balance to form oxidative stress, along with promoting apoptosis of renal cells^[4]. Additionally, AAI promoted apoptosis in SSCs, which was accompanied by upregulation of caspase 3, P53 and BAX expression and downregulation of Bcl-2 expression, and suppressed autophagy, which was accompanied by upregulation of P62 expression and downregulation of ATG5 and LC3B expression, in a concentration-dependent manner. AAI (Aristolochic acid I) impaired spermatogenesis in rats, as identified by degeneration of the seminiferous epithelium, and increased apoptosis of testicular cells^[5]. The mechanism of AA-I-induced hepatotoxicity was associated with oxidative-stress-mediated apoptosis and mitochondrial damage^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03066921	End Stage Renal Disease	Not Applicable	Completed	-	Taiwan ... more >> Tungs' Taichung MetroHarbour Hospital Taichung, Taiwan Collapse <<
NCT01503645	-	-	Unknown	-	Taiwan ... more >> Far Estern Memorial Hospital Not yet recruiting Pan-Chiao, Taipei, Taiwan, 22060 National Taiwan University Hospital Recruiting Taipei, Taiwan, 10051 Contact: Kwan-Dun Wu, MD, PhD +886-2-23123456 ext 5014 kdw@ntumc.org Principal Investigator: Fe-Lin L Wu, Ph.D. Collapse <<
NCT00867633	-	-	Unknown	March 2012	Taiwan ... more >> National Taiwan University Hospital Recruiting Taipei, Taiwan, 100 Contact: Yeong-Shiau Pu, Ph.D. 886-2-23123456 ext 65249 yspu@ntu.edu.tw Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9302 mL
- 14.6511 mL
- 29.3022 mL
- 5 mM
- 0.5860 mL
- 2.9302 mL
- 5.8604 mL
- 10 mM
- 0.2930 mL
- 1.4651 mL
- 2.9302 mL

技术信息

CAS号

313-67-7

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H11NO7

运输

蓝冰

分子量

341.27

别名

马兜铃酸 A;Aristolochic acid I;TR 1736;马兜铃酸Ⅰ

溶解度

DMSO	23.0 mg/mL (67.4 mM) warming
Water	insoluble

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